Question

What is the significant difference between the induced fit model and the lock and key model of enzyme action? a) The induced fit model proposes a rigid, complementary fit between the enzyme and substrate, while the lock and key model suggests a flexible fit.

b) The lock and key model involves a conformational change in the enzyme upon substrate binding, while the induced fit model assumes a static enzyme structure.
c) The lock and key model emphasizes the importance of non-covalent interactions, while the induced fit model focuses on covalent bonding.
d) The induced fit model describes a perfect geometric match between the enzyme and substrate, while the lock and key model accounts for structural adjustments in both.

Answer 1

The lock and key model suggests a rigid, perfect fit between enzyme and substrate, whereas the induced fit model proposes that the enzyme's active site is flexible and adjusts its shape for an optimal fit.

Step-by-step explanation:

The significant difference between the induced fit model and the lock and key model of enzyme action relates to the flexibility of the enzyme's active site when binding to the substrate. The lock and key model proposes that the enzyme's active site and substrate are a perfect geometric match, much like a key fits into a specific lock, implying a rigid, unchanging structure of the active site. In contrast, the induced fit model suggests that the active site is flexible and undergoes a conformational change to accommodate the substrate more effectively, adapting its shape for a precise fit during the formation of the enzyme-substrate complex.