Final answer:
The settlers of the Appalachians mostly came from England, Ireland, and Scotland, which is part of the Upland South region. Therefore, the correct answer is b. Scotland.
Step-by-step explanation:
Most of the settlers of the Appalachians came from several European countries, predominantly from England, Ireland, and Scotland. These settlers were described as being a part of the Upland South, which contrasts with the Lowland South regarding culture and agricultural practices due to the poor farming conditions leading to less reliance on plantation agriculture and slavery. Hence, the correct answer to the multiple-choice question is b. Scotland.