Question

A patient suffers a heart attack, which leads to a drop in cardiac output and blood pressure.

Oxygen delivery to the tissues, including the kidneys, is significantly decreased. Since the tubules are energy-dependent, requiring considerable Na⁺/K⁺ ATPase activity for tubular reclamation, what do you think the clinical result of the patient's hypotension will be At the tubules?
A. the tubules will receive more blood.
B. the tubules will receive less blood.
C. more ATP is generated to power more tubular reclamation.

Answer 1

The clinical result of the patient's hypotension will be that the tubules will receive less blood, leading to compromised tubular reclamation due to reduced ATP generation for Na+/K+ ATPase activity.

Step-by-step explanation:

The clinical result of the patient's hypotension at the tubules will be B. the tubules will receive less blood. During a heart attack, cardiac output and blood pressure decrease, leading to compromised oxygen delivery to tissues, including the kidneys. The tubular reclamation process in the kidneys requires significant Na+/K+ ATPase activity, which is energy-dependent.

This situation leads to inadequate ATP generation, which is necessary for active transport mechanisms, such as Na+/K+ ATPase in tubular function. Thus, the energy-dependent reabsorption processes of the tubules are compromised, leading to less efficient reclamation of water and electrolytes like Na+. Sustained hypotension can cause further kidney damage due to inadequate perfusion and subsequent ischemia.