Final answer:
The Indigenous Peoples had the most difficult way of life due to long-term poverty, inadequate education, cultural dislocation, and high rates of unemployment.
Step-by-step explanation:
The Native American group that had the most difficult way of life were the Indigenous Peoples. For centuries, they suffered from degradation and still face long-term poverty, inadequate education, cultural dislocation, and high rates of unemployment. They also have lower life expectancies than most groups in the United States.