Final answer:
Thomas Jefferson's ultimate goal in terms of Lewis's interactions with Native Americans was to promote coexistence and acculturation, with the aim of transforming native peoples and allowing for the expansion of white settlers. However, Jefferson's vision failed to consider the existing practices and cultures of many native groups.
Step-by-step explanation:
Thomas Jefferson's ultimate goal in terms of Lewis's interactions with Native Americans was to promote coexistence and acculturation. He believed that by exposing native peoples to American ways of life and agriculture, they would gradually adopt these practices and require less land, allowing for expansion of white settlers. However, Jefferson's vision failed to recognize that many native groups were already productive agriculturalists and had their own distinct cultures. His policies also ignored the fact that some native groups would resist encroachment and be displaced by white settlers.