Question

T/F: initial activation of naive CD8 T cell by infected DC in secondary lymphoid tissue and mature cytotoxic T cell's killing of infected cells in periph tissue require interactions of MHC I with both TCR and CD8

Answer 1

True. The initial activation of a naive CD8 T cell by an infected dendritic cell (DC) in secondary lymphoid tissue and the subsequent killing of infected cells by mature cytotoxic T cells in peripheral tissue require interactions of MHC I with both the TCR and CD8.

Step-by-step explanation:

True. The initial activation of a naive CD8 T cell by an infected dendritic cell (DC) in secondary lymphoid tissue and the subsequent killing of infected cells by mature cytotoxic T cells in peripheral tissue require interactions of MHC I with both the T cell receptor (TCR) and CD8. Naive CD8+ T cells recognize antigens presented by infected cells via their MHC I molecules. This interaction triggers the activation of the T cell, leading to the differentiation and maturation of cytotoxic T cells, which can then recognize and kill the infected cells.