Final answer:
The distortion caused by TBP binding facilitates other transcription factors binding, stabilizes the pre-initiation complex, and allows for the recruitment of RNA polymerase II, necessary for transcription.
Step-by-step explanation:
The distortion caused by the binding of the Transcription Factor 2D-TBP complex plays a significant role in the initiation of transcription in eukaryotic cells.
When the TATA-binding protein (TBP) within the Transcription Factor IID (TFIID) binds to the TATA box in the promoter region, it induces a distortion in the DNA structure.
This bending is crucial because it facilitates the unwinding of the DNA and allows other transcription factors to bind more efficiently, thereby stabilizing the pre-initiation complex.
Additionally, this conformational change enables the recruitment of RNA polymerase II, which is essential for the transcription of protein-coding genes.