Question

Which of the following statements is FALSE?

-TPB positions TFIIB.
-TFB is present in Archaea.
-The cyclin-like domains (R1 R2) of TFIIB block the RNA exit pore of RNA pol II.
-TFIID is considered the Commitment Factor for RNA pol II.
-TFIIB is found in a major group of prokaryotes.

Answer 1

The false statement among those provided is that TFIIB is found in a major group of prokaryotes; TFIIB is specific to eukaryotes.

Step-by-step explanation:

The question pertains to the role of different transcription factors in the process of eukaryotic transcription initiation. Among the statements provided, the false one is that TFIIB is found in a major group of prokaryotes. TFIIB is actually specific to eukaryotes and is not found in prokaryotes. Transcription factor B (TFB) is indeed present in Archaea, highlighting the evolutionary link between archaea and eukaryotes. On the other hand, TFIID, which includes the TATA-binding protein (TBP), is the commitment factor for RNA polymerase II as it is essential for the recruitment of other transcription factors and RNA polymerase II itself to form the preinitiation complex.