Question

Which of the following statements is TRUE about B-1 B cells and MZB cells?

A. Both are self-renewing in the periphery, not requiring replacement from bone marrow.
B. Both can respond to TI antigen.
C. Both do not undergo SHM.
D. Both A and B
E. All of the above

Answer 1

The true statement about B-1 B cells and MZB cells is that both can respond to TI antigen. B-1 B cells are self-renewing and have limited SHM, while MZB cells are not self-renewing and do undergo SHM.

Step-by-step explanation:

The B-1 B cells and MZB (Marginal Zone B) cells have distinct characteristics in the immune system. Answering which of the statements is true about B-1 B cells and MZB cells, the correct answer is B. Both can respond to TI antigen. Both of these B cell subsets are able to respond to T-independent (TI) antigens, which are antigens that can trigger an immune response without the help from T cells.

However, B-1 B cells and MZB cells differ in how they self-renew and whether they undergo somatic hypermutation (SHM). B-1 B cells are self-replenishing and are thought to undergo limited SHM, while MZB cells do not renew themselves in the periphery and do require replacement from the bone marrow. Furthermore, MZB cells can also undergo SHM, although it occurs primarily in germinal centers.