Question

The conversion of fructose 1,6-bisphosphate is catalyzed by a fructose 1,6-bisphosphatase and is one of the final steps in gluconeogenesis. Which of the following molecules is an allosteric activator of this enzyme?

a) ATP

b) AMP

c) Citrate

d) Fructose 2,6-bisphosphate

Answer 1

Fructose 2,6-bisphosphate is the allosteric activator that increases the activity of fructose 1,6-bisphosphatase, a key enzyme in gluconeogenesis.

Step-by-step explanation:

The conversion of fructose 1,6-bisphosphate is a crucial step in gluconeogenesis, which is catalyzed by the enzyme fructose 1,6-bisphosphatase. An allosteric activator of this enzyme plays a significant role in regulating this metabolic pathway. The allosteric activator in question is d) Fructose 2,6-bisphosphate. This molecule is a potent regulator of gluconeogenesis and glycolysis, as it can positively affect the rate of these processes. Specifically, fructose 2,6-bisphosphate increases the activity of fructose 1,6-bisphosphatase, facilitating gluconeogenesis by promoting the conversion of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.