Final answer:
The rate of diffusion through tissue is mainly proportional to the concentration gradient, the available surface area, and the membrane thickness, with factors like temperature affecting the diffusion constant.
Step-by-step explanation:
The rate of diffusion through tissue is primarily proportional to factors such as the concentration gradient, the surface area available for diffusion, and the membrane thickness. Specifically, the rate of diffusion is higher when there is a larger surface area and a steep concentration gradient. Conversely, a thicker membrane can slow down diffusion. Additionally, factors like temperature can influence the rate by affecting the diffusion constant, as increased temperature generally increases diffusion rates.
While pressure, volume, and time are related to gas laws and dynamics, they are not the primary focus when discussing the proportionality of diffusion through tissues.