Question

Which of the following is a requirement for long-term memory?

1) Adenylyl cyclase
2) Synthesis of new protein
3) Sodium influx
4) Repeated phosphorylation

Answer 1

Long-term memory requires the synthesis of new protein.

Step-by-step explanation:

Long-term memory requires the synthesis of new protein.

Synaptic plasticity, which is the cellular basis for long-term memory formation, involves the insertion of more AMPA receptors into the postsynaptic membrane. This insertion requires protein synthesis. Furthermore, protein kinases activated by calcium entry can phosphorylate various postsynaptic targets, including AMPA receptors, which enhances their function and contributes to long-term memory.