Question

In a comparative genomic hybridization experiment, the ratio of green to red fluorescence was 2. This indicates that a particular chromosome carries a(n) ______?

1) Gene mutation
2) Gene duplication
3) Gene deletion
4) Gene translocation

Answer 1

A ratio of green to red fluorescence of 2 in comparative genomic hybridization indicates a gene duplication in the chromosome.

Step-by-step explanation:

In a comparative genomic hybridization experiment, if the ratio of green to red fluorescence is 2, it indicates that there has been an increase in the number of copies of a particular chromosomal region in the genome being examined. Considering the provided options, the correct answer is that the chromosome carries a gene duplication. Large scale mutations can include deletions, duplications, inversions, and translocations. A gene duplication results in multiple copies of a region of a chromosome and can be indicative of an increase in dosage of certain genes, which might confer an advantage or a disadvantage, depending on the genes involved and their functions in the organism.