Final answer:
The smallpox advertisement in 1700 was significant because it brought attention to the practice of variolation and laid the foundation for the development of vaccination.
Step-by-step explanation:
In the 18th century, a practice known as variolation was introduced as a method to prevent smallpox. Variolation involves infecting an uninfected person with a small amount of the smallpox virus to create a milder infection and provide immunity. This practice was significant because it showed that deliberate infection could provide protection against disease, laying the groundwork for the development of vaccination.
Edward Jenner further expanded on this concept in the late 18th century when he introduced the practice of vaccination using cowpox virus to prevent smallpox. Vaccination replaced variolation as a safer and more effective method of preventing smallpox.
Overall, the smallpox advertisement in 1700 was significant because it brought attention to the practice of variolation and laid the foundation for the development of vaccination.