Final answer:
The Ohio River Valley is significant due to its fertile soil and the abundance of plants, animals, and fresh water, making it an ideal location for farming, hunting, and fishing.
Step-by-step explanation:
The Ohio River Valley is significant because its fertile soil could support profitable farms. The region had a variety of plants and animals, making it an excellent location for hunting and fishing. The rivers and lakes in the area also provided fresh water and encouraged settlement.