Final answer:
Food scarcity and cultural misunderstandings were two key challenges the Pilgrims and Native Americans faced in Of Plymouth Plantation, leading to the eventual conflict known as King Philip's War. Option b is correct.
Step-by-step explanation:
The two major challenges and concerns that faced the Pilgrims and Native Americans in Of Plymouth Plantation include food scarcity and cultural misunderstandings. Severe weather during the winter of 1620-1621 caused many Pilgrims to suffer from starvation, disease, and malnutrition. The assistance of Native Americans, such as Samoset and Squanto, was crucial in teaching the Pilgrims agricultural techniques to overcome these hardships.
However, as the Pilgrims began to thrive, they increasingly encroached on Native lands, leading to cultural conflicts and political disputes, which later escalated into King Philip's War, a reflection of deep-seated tensions and the struggle for survival and sovereignty.