Final answer:
Conducting role-based training for privileged users is the most effective solution to prevent or deter attacks by insider threats in a large enterprise.
Step-by-step explanation:
The most effective solution to prevent or deter attacks by insider threats in a large enterprise experiencing high levels of malicious activity would be to conduct role-based training for privileged users. This training should highlight common threats against them and cover best practices to thwart attacks.
By educating privileged users about the specific risks they face and teaching them how to identify and mitigate these risks, the enterprise can greatly reduce the success rate of targeted attacks against them and network file shares.
Other measures mentioned, such as increasing the frequency of vulnerability scanning and patching, enforcing command shell restrictions, modifying rules of behavior, implementing full-disk encryption, and application blacklisting, can also have a positive impact on security. However, role-based training directly addresses the issues related to insider threats and is the most likely to prevent or deter such attacks.