Final answer:
The difference between a point mutation and a chromosome mutation lies in the amount of DNA that is changed; point mutations affect single nucleotides, while chromosome mutations involve more extensive alterations.
Step-by-step explanation:
The difference between a point mutation and a chromosome mutation is primarily based on C) The amount of DNA that is changed. A point mutation involves a change in a single nucleotide in DNA, which could lead to a silent, missense, or nonsense mutation.
Meanwhile, a chromosome mutation affects the structure of a chromosome, resulting in a more extensive alteration of the genetic material, which can include deletions, insertions, translocations, or large-scale changes to entire sections of DNA. The impacts of these mutations vary, with point mutations having less potential to disrupt overall genetic function in comparison to chromosomal alterations.