Final answer:
The Interior Plains and Prairies region, covered by shallow seas during the Paleozoic and Mesozoic eras, consists of Paleozoic marine rocks.
Step-by-step explanation:
The physiographic region with a history of being covered by Epeiric seas during the Paleozoic and Mesozoic eras is the Interior Plains and Prairies. This region is known for its expansive flat lands that consist largely of undeformed Paleozoic marine rocks, such as limestones and shales. These sedimentary rocks were deposited in environments like shallow seas, which covered the region during the ancient geological eras.