Final answer:
The synthesis of Trp-Met-Arg can be done via solid-phase or solution-phase method, each involving sequential addition of amino acids with intermediate protective steps and purification.
Step-by-step explanation:
The synthesis of Trp-Met-Arg peptide can be approached through either solid-phase synthesis or solution-phase synthesis. In solid-phase synthesis, the first amino acid is attached to an insoluble resin, followed by sequential addition of amino acids using protective groups and activation steps to ensure specificity and yield. The peptide is then cleaved from the resin to generate the final product. On the other hand, solution-phase synthesis involves the coupling of amino acids in solution, often employing protective groups to shield the functional groups not involved in bond formation, and purification steps to isolate the desired product after each coupling reaction.
Within the context of the information provided, for example, Scheme 1 outlines the synthesis of a modified nucleoside, which while not directly describing peptide synthesis, involves similar principles of protecting group strategies and sequential reactions to build complex molecules. Specifically, the synthesis of compounds 1-3 detailed in the question appears to involve palladium-catalyzed cross-coupling and protective group manipulations as seen in various schemes such as Scheme 2 for isoxazolidinyl-triazoles.