Final answer:
Antibodies in celiac sprue are autoantibodies produced, causing an immune response to gluten and damaging the microvilli in the small intestine. This leads to nutrient malabsorption and gastrointestinal symptoms. Diagnosis involves serological tests and biopsy, followed by a gluten-free diet as treatment.
Step-by-step explanation:
The antibodies to get in celiac sprue refer to the autoantibodies that the immune system produces in response to ingestion of gluten, a protein found in wheat, barley, and rye. In individuals with celiac disease, these antibodies target and damage the microvilli lining the small intestine, which leads to a number of gastrointestinal symptoms as well as malabsorption of nutrients. Diagnosis of celiac disease typically involves serological tests for IgA antibodies to components of gluten, tissue transglutaminase, and endomysium. If these tests are positive, an endoscopy and biopsy of the duodenal mucosa are usually performed to confirm the diagnosis. The primary treatment for celiac disease is a strict gluten-free diet, which can alleviate symptoms and reduce the risk of complications. Furthermore, continuous monitoring is crucial since approximately 1% of individuals in the United Kingdom have been found to test positive for celiac disease antibodies, yet may not display symptoms.
Related Autoimmune Conditions
Other autoimmune conditions that affect the digestive system include type I diabetes mellitus, where antibodies target the beta cells of the pancreas, and autoimmune disorders involving the thyroid-stimulating hormone receptor.