Final answer:
The major stakeholders in a new system can be varied and include individuals or groups affected by the system's outcomes, such as religious leaders, politicians, educators, and business owners in a program, as well as economic and social groups in a historical context, or shareholders and other affected parties in a business scenario.
Step-by-step explanation:
In the context of stakeholder theory, the major stakeholders in a new system include various individuals or groups that have a stake in, or are affected by, the implementation and success of a program or a policy. For instance, in the substance abuse prevention program described, the potential stakeholders were religious leaders, politicians, educators, local business owners, and others who were identified as being knowledgeable about or invested in the program. In the broader sense, during historical instances such as the ratification of the U.S. Constitution, stakeholders included the federalists, republicans, and various economic and social groups like large farmers, merchants, artisans, and those belonging to different estates (commoners, nobility, and clergy). In the business context, shareholders and stakeholders are distinguished, where shareholders are the owners of a company, while stakeholders encompass a wider group affected by a company's operations including employees, customers, and the community.