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Under different conditions of isolation, different conformations of DNA are seen. Describe some of the characteristics of the following types of DNAS.

a. A-DNA
b. B-DNA
c. C-DNA
d. D-DNA
e. E-DNA
f. P-DNA
g. Z-DNA

1 Answer

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Final answer:

DNA has several conformational forms, including A-DNA, B-DNA, and Z-DNA. B-DNA is the most common in cells, while A-DNA is found under dehydrating conditions, and Z-DNA has a left-handed helix and can occur in regions with certain base sequences.

Step-by-step explanation:

Different Structural Forms of DNA

DNA, or deoxyribonucleic acid, is the genetic material for all living organisms. It comprises two strands that form a double helix structure. The DNA molecule can exist in several conformations, including A-DNA, B-DNA, and Z-DNA, which can form under various physiological conditions.

A-DNA

A-DNA is a rarer form that is right-handed with a deep and narrow major groove and a shallow and wide minor groove. It occurs under dehydrating conditions and has 11 base pairs per turn.

B-DNA

B-DNA is the most common DNA conformation in cells, featuring a right-handed helix. It presents with 10.5 base pairs per turn and has a wide major groove and a narrow minor groove, facilitating the binding of DNA-binding proteins during processes like transcription and replication.

Z-DNA

Z-DNA is a left-handed helix, which makes it distinct from the other forms. It has a zigzag sugar-phosphate backbone with a shallow minor groove and no major groove, usually occurring in regions with alternating purine and pyrimidine sequences.

The other types of DNA conformations mentioned (C-DNA, D-DNA, E-DNA, and P-DNA) are less well-characterized and not typically found under physiological conditions. DNA's structural flexibility is critical for its function in replication, transcription, and genetic recombination.

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