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Why do smaller fragments of DNA migrate further in an agarose gel during electrophoresis.

User Kmore
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Final Answer:

Smaller fragments of DNA migrate further in an agarose gel during electrophoresis because they experience less resistance from the gel matrix.

The gel matrix acts as a sieve, and smaller fragments can more easily navigate through the pores, allowing them to travel a greater distance in the electric field compared to larger fragments.

Step-by-step explanation:

The final answer reiterates that smaller DNA fragments encounter less hindrance from the gel matrix, which functions like a sieve. The explanation emphasizes that smaller fragments can navigate through the gel pores more easily, leading to a more extended migration distance during electrophoresis.

User JGS
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