Final answer:
True, a prophase I cell has a 2n chromosome number and 4C DNA content due to DNA replication in the S phase preceding meiosis.
Step-by-step explanation:
The statement is true: If a typical G1 nucleus is 2n and contains 2C DNA, then a prophase I cell would be 2n and contains 4C of DNA. During the G1 phase of the cell cycle, a eukaryotic cell has a diploid number of chromosomes (2n) and each chromosome consists of a single chromatid, which is why we refer to the DNA content as 2C. Following the S phase, where DNA replication occurs, the amount of DNA doubles (4C), but the number of chromosomes remains the same (2n), because the duplicated chromosomes, known as sister chromatids, are still joined together. During prophase I of meiosis, which follows the interphase, a cell still has the same number of chromosome sets (2n) but now each chromosome has replicated into two chromatids, hence having 4C DNA content.