Final answer:
Tobacco was first domesticated in the Andes Mountains around 3000 BCE and is the correct answer to the question.
Step-by-step explanation:
The Andes Mountains have been the site of extensive crop domestication as Native Americans made significant contributions to global agriculture. Given the question of which crop was first domesticated in the Andes Mountains around 3000 BCE, the correct answer is A. Tobacco. Tobacco was indeed a New World crop that played a significant role in both the culture and the economy of the indigenous peoples of the Americas.
Furthermore, the Andean region was known for the cultivation and domestication of other important crops such as maize, potatoes, cassava, hot peppers, tomatoes, beans, cocoa, and quinoa. These were developed over time through selective breeding and adaptation to various climate conditions. Therefore, it's clear that tobacco is one of the significant crops that were first used by the peoples in this region long before European contact.