Question

In the IP3-kinase/Akt pathway, a survival signal is triggered?

Answer 1

In the IP3-kinase/Akt pathway, a survival signal is triggered, leading to the activation of multiple downstream signaling pathways that promote cell survival and inhibit apoptosis.

Step-by-step explanation:

In the IP3-kinase/Akt pathway, a survival signal is triggered. This pathway is part of the cellular signaling process that regulates cell survival and prevents apoptosis (programmed cell death).

When a survival signal is received, the IP3-kinase/Akt pathway is activated. The pathway involves a series of steps:

1. First, a signaling molecule binds to a receptor on the cell surface.
2. This activates an enzyme called IP3-kinase, which produces inositol trisphosphate (IP3).
3. IP3 then binds to and opens calcium channels on the endoplasmic reticulum, allowing calcium ions to enter the cytoplasm.
4. Calcium ions activate another enzyme called Akt (protein kinase B) by phosphorylating it.
5. Akt then phosphorylates various target proteins involved in cell survival, leading to the activation of multiple downstream signaling pathways that promote cell survival and inhibit apoptosis.