Question

Developing B cells that fail to make productive D to J heavy-chain rearrangements on both homologous chromo- somes

a. die by apoptosis in the bone marrow
b. will rearrange heavy-chain loci multiple times until a productive rearrangement is made
c. undergo clonal proliferation
d. upregulate expression of transcription factors E2A and EBF
e. fail to rearrange V to DJ.

Answer 1

B cells that fail to make productive D to J heavy-chain rearrangements on both chromosomes will undergo clonal proliferation and upregulate the expression of transcription factors E2A and EBF. They will fail to rearrange V to DJ.

Step-by-step explanation:

1. B cells that fail to make productive D to J heavy-chain rearrangements on both homologous chromosomes will undergo clonal proliferation.
2. These B cells will upregulate the expression of transcription factors E2A and EBF.
3. They will fail to rearrange V to DJ.