Question

All of the following are properties of B-1 cells except

a. They exhibit polyspecificity.
b. They arise during fetal development.
c. They express CD5 on their cell surface.
d. They are commonly associated with the cause of chronic lymphocytic leukemia (CLL).
e. They have extensive N nucleotide diversity in VDJ junctions.

Answer 1

B-1 cells are a type of B cell that exhibits several unique properties, including polyspecificity, CD5 expression, and extensive N nucleotide diversity. However, they are not commonly associated with the cause of chronic lymphocytic leukemia (CLL).

Step-by-step explanation:

B-1 cells are a type of B cell that exhibits several unique properties. However, one property that they do not exhibit is being commonly associated with the cause of chronic lymphocytic leukemia (CLL).

B-1 cells are primarily found in the peritoneal and pleural cavities and are known for their polyspecificity, meaning they can recognize and bind to a variety of antigens. They also express CD5 on their cell surface, which is a characteristic often associated with B-1 cells. Additionally, B-1 cells have extensive N nucleotide diversity in VDJ junctions, contributing to their ability to recognize a wide range of antigens.