Question

Which of the following statements regarding negative selection of B cells is correct?

a. Negative selection is a process that occurs in secondary lymphoid organs.
b. Negative selection is a process that occurs in the bone marrow but not in secondary lymphoid organs.
c. Negative selection ensures that B cells bearing receptors for pathogens that will not be encountered in a person's lifetime are eliminated to make room for B cells bearing useful receptors.
d. Negative selection eliminates B cells at the end of an infection as a means of terminating an immune response once the pathogen has been removed from the body.
e. Negative selection ensures that autoreactive B cells are prohibited from emerging in the body.

Answer 1

Negative selection of B cells occurs in the bone marrow and prohibits autoreactive B cells from emerging in the body to minimize the risk of autoimmunity.

Step-by-step explanation:

Negative selection of B cells is a process that occurs in the bone marrow, not in secondary lymphoid organs. It ensures that autoreactive B cells, which can bind to self-antigens, are prohibited from emerging in the body. Self-reactive B cells can be eliminated by apoptosis, edited to modify their receptors, or induced into a state of anergy where they are unable to function. This process helps to minimize the risk of autoimmunity.