Question

G-6-Phosphatase is not found in ___________ or __________; these tissues are glucose-6-P (producers/consumers) and use G-6-P for ______________ via _________________________ (G-6-P -> F-6-P).

Answer 1

Glucose-6-Phosphatase is absent in muscle and brain tissues which are glucose-6-P producers utilizing it for energy through glycolysis, not glucose production.

Step-by-step explanation:

G-6-Phosphatase is not found in muscle or brain tissues; these tissues are glucose-6-P producers and use G-6-P for glycolysis via phosphoglucoisomerase (G-6-P -> F-6-P).

Muscle and brain tissues have high energy demands, typically utilizing glucose-6-phosphate (G-6-P) synthesized by hexokinase for energy production rather than for glucose production, which would require the presence of glucose-6-phosphatase.

The phosphorylation of glucose by hexokinase is a critical step in ensuring that glucose remains within the cell to enter the glycolytic pathway, being subsequently converted to fructose-6-phosphate (F-6-P) by an isomerase.