Final answer:
The major advantage of the SEM approach is its enhanced specificity over hand swabbing.
Step-by-step explanation:
The statement is true. The major advantage of the SEM approach for primer residue detection is its enhanced specificity over hand swabbing.
The SEM (scanning electron microscope) provides images by using secondary electrons produced by the primary beam interacting with the surface of the sample. It does not require a thin sample and provides a 3-D view. However, its resolution is about ten times less than a TEM (transmission electron microscope).
In the context of primer residue detection, SEM allows for more accurate and specific detection compared to hand swabbing.