Final answer:
Enzymatic reactions can be affected by temperature, pH, substrate concentration, product concentration, and protein misfolding. Increases or decreases in temperature and extreme pH values can disrupt the active site of enzymes and affect their functioning.
Step-by-step explanation:
Enzymatic reactions can be affected by several factors, including temperature, pH, substrate concentration, product concentration, and protein misfolding. Increases or decreases in temperature outside the optimal range can affect the chemical bonds in the enzyme's active site, making it less suitable for binding substrates. Extreme pH values can also cause enzymes to denature and lose their activity.