Final answer:
Henry VIII's split with the Roman Catholic Church was primarily driven by his desire for a male heir and his need to annul his marriage to Catherine of Aragon.
Step-by-step explanation:
The main reason for Henry VIII's split with the Roman Catholic Church was c) Desire for a male heir. While Henry VIII initially stood in opposition to the Reformation, he desired a male heir to the Tudor monarchy.
When the Pope refused his request to annul his marriage to Catherine of Aragon and allow him to remarry, Henry decided to create a new national Protestant church, the Church of England, with himself as its head. This allowed him to annul his own marriage and marry Anne Boleyn.