Question

What are the antibodies seen in pts with PBC?

Answer 1

In patients with Primary Biliary Cholangitis (PBC), specific autoantibodies including anti-mitochondrial antibodies (AMA) and potentially others like antinuclear antibodies (ANA) and smooth muscle antibodies (SMA) can be detected.

Step-by-step explanation:

Patients with Primary Biliary Cholangitis (PBC) often have specific autoantibodies in their blood. These include anti-mitochondrial antibodies (AMA), which are detectable in approximately 95% of patients with PBC and serve as a hallmark for the disease. Other non-specific autoantibodies may also be present, such as antinuclear antibodies (ANA) and smooth muscle antibodies (SMA). Since PBC is an autoimmune disorder, the body's immune system inappropriately produces these antibodies against its own cellular components, specifically targeting the mitochondria within the cells of the bile ducts. Recognizing these antibodies can aid in diagnosis and help differentiate PBC from other liver diseases.In patients with primary biliary cirrhosis (PBC), specific antibodies called antimitochondrial antibodies (AMAs) are commonly seen. These antibodies target the mitochondria, which are the energy-producing structures within cells. The presence of AMAs is an important diagnostic marker for PBC, as they are found in up to 95% of patients with this condition.

Answer 2

Patients with Primary Biliary Cholangitis (PBC) commonly have antimitochondrial antibodies (AMA) and may also have antinuclear antibodies (ANA). These autoantibodies are critical for the diagnosis and management of PBC. Diagnostic tests such as IEP or ELISA can detect these antibodies in serum.

Step-by-step explanation:

Patients with Primary Biliary Cholangitis (PBC) often present with specific autoantibodies. One of the most commonly seen autoantibodies in PBC is antimitochondrial antibodies (AMA). PBC is considered an autoimmune disease, and the detection of these autoantibodies is crucial for the diagnosis and management of the condition. Other non-organ-specific antibodies may also be present, such as antinuclear antibodies (ANA), and these can further support the diagnosis of PBC when combined with clinical features and other laboratory findings.

Clonal proliferation of B cells and the resultant production of certain antibodies is a hallmark of autoimmune conditions like PBC. Indeed, once a B cell is activated in such disorders, it can undergo clonal proliferation, with the daughter cells differentiating into plasma cells which then act as factories, secreting large quantities of antibodies specific to the disease.

Diagnostic tests for PBC may include procedures such as Immunoelectrophoresis (IEP) or enzyme-linked immunosorbent assay (ELISA) to detect these characteristic autoantibodies in the patient's serum.