Question

What is the triad of Felty syndrome?

1) Rheumatoid arthritis, splenomegaly, and neutropenia
2) Liver cirrhosis, joint inflammation, and thrombocytopenia
3) Glomerulonephritis, facial rash, and proteinuria
4) Dry eyes, dry mouth, and joint pain

Answer 1

Felty syndrome includes a triad of rheumatoid arthritis, splenomegaly, and neutropenia, and is a rare complication associated with rheumatoid arthritis and immune dysfunction.

Step-by-step explanation:

The triad of Felty syndrome consists of 1) Rheumatoid arthritis, splenomegaly, and neutropenia. This syndrome is a rare complication of chronic rheumatoid arthritis, characterized not just by its classic triad, but also by various extra-articular manifestations. While rheumatoid arthritis induces chronic inflammation in the joints, splenomegaly and neutropenia are indicative of potential immune dysfunction and an increased risk of infection, respectively. Diagnosis and management of Felty syndrome require careful clinical assessment and a multidimensional approach that can include medication and monitoring for infection due to the associated neutropenia.

The triad of Felty syndrome consists of:

Rheumatoid arthritis: This is a chronic inflammatory joint disease that causes joint pain, swelling, and deformity.

Splenomegaly: Enlargement of the spleen.

Neutropenia: Low levels of neutrophils, a type of white blood cell that helps fight infection.

In Felty syndrome, the combination of these three symptoms is characteristic and helps differentiate it from other conditions. It is most commonly seen in individuals with long-standing rheumatoid arthritis.

Answer 2

1) Rheumatoid arthritis, splenomegaly, and neutropenia

Step-by-step explanation:

Felty syndrome is a rare complication of rheumatoid arthritis (RA) characterized by the triad of rheumatoid arthritis, splenomegaly, and neutropenia. Rheumatoid arthritis is an autoimmune disease that primarily affects the joints, causing inflammation and pain. In Felty syndrome, the combination of RA with an enlarged spleen (splenomegaly) and low white blood cell count (neutropenia) distinguishes it from typical rheumatoid arthritis cases.

The enlarged spleen is believed to result from the accumulation of immune complexes and abnormal white blood cells. Neutropenia, a decrease in the number of neutrophils (a type of white blood cell), can lead to an increased risk of infections. Felty syndrome is considered a severe manifestation of rheumatoid arthritis and requires careful management to address both the joint inflammation and the associated complications, such as infections due to neutropenia.

In summary, the triad of Felty syndrome consists of rheumatoid arthritis, splenomegaly, and neutropenia. This unique combination of symptoms helps clinicians distinguish Felty syndrome from other rheumatoid arthritis-related conditions. Understanding and recognizing this triad are crucial for appropriate diagnosis and management of patients with Felty syndrome.