Final answer:
Released to the outside and follow the secretion pathway (contain a ER signal sequence) is the protein.
Step-by-step explanation:
Proteins that contain an ER signal sequence are released to the outside and follow the secretion pathway in cells. This process begins in the rough endoplasmic reticulum (RER), where the proteins are synthesized on bound ribosomes. As the proteins are synthesized, an N-terminal signal sequence, also known as a signal peptide, emerges and interacts with the RER membrane. The signal peptide directs the growing secretory polypeptide to the lumen of the RER.
Once the newly synthesized proteins are deposited into the lumen of the RER, they undergo structural modifications, such as folding or addition of side chains. If the modified proteins are not destined to stay in the RER, they will travel by small, membrane-bound transport vesicles that bud from the RER's membrane to the Golgi apparatus. In the Golgi, the proteins are further modified and sorted before being sent to their final destination.
Some proteins are packaged into secretory vesicles that bud from the Golgi's trans face, and these vesicles can either deposit their contents into other parts of the cell or fuse with the plasma membrane and release their contents outside the cell. So therefore proteins with an ER signal sequence are released through the secretion pathway. They are synthesized in the RER and modified in the Golgi before being packaged into secretory vesicles and released outside the cell.