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Extended haplotype homozygosity (EHH)

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Extended haplotype homozygosity (EHH) is a concept in biology used to detect recent positive selection by examining long-range homozygosity of alleles. It involves formulas to assess genetic bottlenecks and is interlinked with processes such as heritability, inbreeding depression, macroevolution, and microevolution, as well as principles like Hardy-Weinberg equilibrium.

Step-by-step explanation:

Extended haplotype homozygosity (EHH) is a concept in Biology that refers to the homozygosity of genetic markers along a shared haplotype and is used to detect recent positive selection in the genome. An extended haplotype is a combination of alleles at adjacent loci on the same chromosome that are inherited together. The EHH test helps to determine if a haplotype shows a disproportionately high frequency and long-range haplotype homozygosity compared to expectations under genetic drift and recombination.

The concept of a genetic bottleneck is demonstrated by the formula [(N1–I) / N1], where N1 is haplotype richness in the native region and I is the haplotype richness in the introduced region. This formula reflects the reduction of genetic variance due to a bottleneck event where a population has been dramatically reduced in size.

Within the context of genetics, the terms such as heritability, honest signal, inbreeding depression, macroevolution, microevolution, and modern synthesis are crucial to understanding the principles of inheritance and the effects of genetic variation on populations. These terms describe the processes and concepts that shape the genetic structure of populations over time and are vital in predicting the outcomes of mating strategies and the impact of environment on genetic diversity.

The question is incomplete, The complete question is given below:

Define Extended Haplotype Homozygosity (EHH) and explain its significance in the context of population genetics.

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