Final answer:
The important goal for Lewis and Clark in dealing with Native Americans was to establish trade routes and alliances, as tasked by President Jefferson.
Step-by-step explanation:
An important goal for Lewis and Clark when dealing with the Native Americans was to establish trade routes and alliances. President Thomas Jefferson tasked them with making contact with Native American tribes to initiate trade and ensure the United States could forge strong relationships that would support American territorial claims and economic interests in the region. They were also tasked with mapping the territory and exploring in the interests of American science and geography.
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