Final answer:
The conflict between the North and the South at the time of the Missouri Compromise was primarily due to differences in regional economies and the issue of slavery.
Step-by-step explanation:
At the time of the Missouri Compromise, there was conflict between the North and the South primarily because of the differences in regional economies. The North was industrialized and had an economy based on manufacturing and commerce, while the South relied heavily on agriculture, particularly the institution of slavery. These economic disparities led to disagreements over issues such as taxation, tariffs, and the expansion of slavery into new territories, which ultimately led to the American Civil War.
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