Final answer:
Tolbutamide and chlorpropamide are 1st generation sulfonylureas. These are oral hypoglycemic drugs used to manage diabetes. Second-generation sulfonylureas are generally more potent and have shorter half-lives.
Step-by-step explanation:
The drugs tolbutamide and chlorpropamide belong to the 1st generation of sulfonylureas. These are oral hypoglycemic drugs used to manage diabetes mellitus. Sulfonylureas are divided into two classes. The first generation includes drugs such as tolbutamide, chlorpropamide along with others like acetohexamide and tolazamide. The second-generation includes drugs such as glipizide, glyburide, and glimepiride which are generally more potent and have shorter half-lives.
Learn more about sulfonylureas