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What are the indications of Televancin? (Protoype of Lipoglycopeptides)

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Final answer:

Televancin is a lipoglycopeptide antibiotic used primarily to treat resistant bacterial infections and Mycobacterium tuberculosis. It mainly targets gram-positive bacteria, due to its structural inability to effectively penetrate the outer membranes of gram-negative bacteria.

Step-by-step explanation:

Televancin is a lipoglycopeptide drug prototype with several key indications.

It is heavily indicated for the treatment of bacterial infections that are resistant to other antibiotics. Similar to its glycopeptide cousin, vancomycin, televancin disrupts bacterial cell wall biosynthesis, ultimately leading to bacterial cell death. However, this function mostly targets gram-positive bacteria, with limited effectiveness on gram-negative bacteria due to the substance's structure and size preventing penetration of their protective outer membranes.

Televancin is also active against Mycobacterium tuberculosis, providing an additional indication for its use in combating tuberculosis infections.

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