The best way to spend your talent points in Hogwarts Legacy is to focus on the skills that you will use most often. This includes developing your combat skills, such as Defense, Dueling, and Potions, as well as your character's attributes, such as Charisma, Agility, and Strength. You should also invest points in your Proficiency skills, such as Charms, Transfiguration, and Herbology, as these will help you progress through the game. Finally, consider investing in your Crafting skills, such as Alchemy and Potioneering, as these will help you create powerful items, as well as make money.