The condition caused by increased levels of plasminogen activator inhibitor 1 (PAI-1) and fibrinogen, which are often present in metabolic syndrome, is thrombosis. Thrombosis is the formation of a blood clot within a blood vessel, which can obstruct the normal flow of blood. Increased levels of PAI-1 and fibrinogen can increase the risk of thrombosis by inhibiting the breakdown of blood clots and promoting blood coagulation.
Metabolic syndrome is a group of risk factors, including obesity, high blood pressure, high blood sugar, and unhealthy cholesterol levels, that increase the risk of developing cardiovascular disease and type 2 diabetes. Elevated PAI-1 and fibrinogen levels are among the metabolic abnormalities that can occur in individuals with metabolic syndrome, contributing to the development of thrombotic events.
In conclusion, increased levels of PAI-1 and fibrinogen, often present in metabolic syndrome, can increase the risk of thrombosis.