The issue in Worcester v. Georgia was the sovereignty of the Cherokee nation. This is best represented by option C.
What was Worcester v. Georgia?
The case of Worcester v. Georgia refers to the question of whether Georgia had autonomy in regulating Cherokee activities within its borders. In this case, the Supreme Court's final decision was that Georgia's laws did not apply to the Cherokee natives because they were a sovereign nation. Because the decision was not effectively enforced as intended, the Trail of Tears occurred. This was a more popularized name for the forceful displacement of the Cherokee people from their homes.