Answer:
The Nathaniel Nawthorne novel that most famously deals with the effects of guilt is The Scarlet Letter.
Step-by-step explanation:
The Scarlet Letter is a book by Nathaniel Hawthorne published in the United States in 1850. The story is set in the seventeenth-century Salem (Massachusetts), colonized by Puritans from England. It tells the story of Hester Prynne, a woman accused of adultery and sentenced to wear on his chest a letter "A", of adulteress. Hester refuses to reveal the identity of her daughter's father, and tries to live with dignity in an unjust and hypocritical society.