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How did Watson and Crick determine base pairing?

User EvR
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Watson and Crick determined the base pairing by using the new information to construct a new double-stranded helix model with the nitrogen bases paired A to T and C to G in the center. This base pairing immediately suggested to Crick that one side of the molecule could serve as a template to exactly replicate DNA sequences to pass on genetic information during cell reproduction. This second, successful model was unveiled in February 1951.
User Alex Chan
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