Answer: The amount of Ra-226 isotope after 1000 years is 162.14 grams and after 2000 years are 105.16 grams
Step-by-step explanation:
The equation used to calculate half life for first order kinetics:

where,
k = rate constant of the reaction = ?
= half life of the reaction = 1599 years
Putting values in above equation, we get:

Integrated rate law expression for first order kinetics is given by the equation:

where,
N = amount left after time 't'
= initial amount = 250 grams
t = time taken =
k = rate constant =

Putting values in above equation, we get:

Putting values in above equation, we get:

Hence, the amount of Ra-226 isotope after 1000 years is 162.14 grams and after 2000 years are 105.16 grams