Final answer:
To achieve a 100 percent probability of Drosophila offspring with red eyes, the cross should be between a male with the genotype XWY (red eyes) and a female that is homozygous for the red-eye allele (XWXW).
Step-by-step explanation:
The question is asking about the inheritance of eye color in Drosophila melanogaster, which is the common fruit fly. Since eye color is an X-linked trait, the Punnett square that would show a 100 percent probability of offspring having red eyes must involve a cross between a male Drosophila having the genotype XWY (red eyes) and a female Drosophila that is homozygous for the red-eye allele (XWXW). In this case, all X chromosomes from the parents carry the dominant red eye color allele (XW), therefore all offspring would inherit at least one XW allele, resulting in red eyes. No Punnett square is given since this is a theoretical scenario; however, based on the description, 100 percent red-eyed offspring would result from the described cross.