Water soluble hormones, such as glycoproteins or peptide hormones, cannot cross the lipidic membrane. The cell receptors for this hormones are located on the surface of the cell membrane. So, this hormones have their main activity on the cell surface.
Fat soluble hormones, for example steroids (cortisol, testosterone, estrogen), can easilly pass through the cell membrane, the receptors for these hormones are found within the cell, in the cytoplasm and the nucleus. These hormones act directly by estimulating the transcription of DNA to produce determined proteins.
The correct option is a.